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□□　Paper　□□ ≪2017年4月≫ NEW!! 1.†Takahashi, M., †Kudo, Y., †Hirata, Y.,Kano, K., Kawana, H., Makide, K., Shinoda, Y., Yabuki, Y., Fukunaga, K., Aoki, J., *Noguchi, T.,*Matsuzawa, A. Trans-fatty acids promote proinflammatory signaling and cell death by stimulating the apoptosis signal-regulating kinase 1 (ASK1)-p38 pathway. J. Biol. Chem., in press. †These authors contributed equally to this work. * Corresponding authors. 2.†Tsuchida, M., †Kogue, Y., †*Noguchi, T., Spadini, C., Hirata, Y., *Matsuzawa, A. BIG1, brefeldin A-inhibited guanine nucleotide- exchange factor 1, governs the recruitment of TRAF2 to TNFR1 signaling complexes. Int. J. Mol. Sci.,17, 1869 (2016). †These authors contributed equally to this work. * Corresponding authors. 3. Shizu, R., Abe, T., Benoki, S., Takahashi, M., Kodama, S., Miayata, M., Matsuzawa, A., Yoshinari, K. PXR stimulates growth factor- mediated hepatocyte proliferation by cross-talk with the FOXO transcription factor. Biochem. J., 473, 257-266, (2016). 4. Miyakawa, K., Matsunaga, S., Kanou, K.,Matsuzawa, A., Morishita, R., Kudoh, A., Shindo, K., Yokoyama, M., Sato, H., Kimura, H., Tamura, T., Yamamoto, N., Ichijo, H., Takaori-Kondo, A., Ryo, A. ASK1 restores the antiviral activity of APOBEC3G by disrupting HIV-1 Vif-mediated counteraction. Nature Communications, 6, 6945 (2015). 5. Eaton, G. J., Zhang, Q. S., Diallo, C., Matsuzawa, A., Ichijo, H., Steinbeck, M. J., Freeman, T. A. Inhibition of apoptosis signal-regulating kinase 1 enhances endochondral bone formation by increasing chondrocyte survival. Cell Death Dis., 5, e1522 (2014). 6. Okada, M., *Matsuzawa, A.,Yoshimura, A., Ichijo, H. Lysosome rupture-activated TAK1-JNK pathway regulates NLRP3 inflammasome activation. J. Biol. Chem., 289, 32926-32936 (2014). * Corresponding author. 7. Mosallanejad, K., Sekine, Y., Ishikura-Kinoshita, S., Kumagai, K., Nagano, T., Matsuzawa, A., Takeda, K., Naguro, I., Ichijo, H. The DEAH-Box RNA helicase DHX15 activates NF-kB and MAPK signaling downstream of MAVS during antiviral responses. Science Signaling, 7, ra40 (2014). 8. Maruyama, T., Araki, T., Kawarazaki, Y., Naguro, I., Heynen, S., Aza- Blanc, P., Ronai, Z., Matsuzawa, A., Ichijo, H. Roquin-2 promotes ubiquitin-mediated degradation of ASK1 to regulate stress responses. Science Signaling, 7, ra8 (2014). 9. Homma, K., Fujisawa, T., Tsuburaya, N., Yamaguchi, N., Kadowaki, H., Takeda, K., Nishitoh, H., Matsuzawa, A., Naguro, I., Ichijo, H. SOD1 as a molecular switch for initiating the homeostatic ER stress response under zinc deficiency. Molecular Cell, 52, 75-86 (2013). 10. Naguro, I., Umeda, T., Kobayashi, Y., Maruyama, J., Hattori, K., Shimizu, Y., Kataoka, K., Kim-Mitsuyama S., Uchida, S., Vandewalle, A., Noguchi, T., Nishitoh, H., Matsuzawa, A., Takeda, K., Ichijo, H. ASK3 responds to osmotic stress and regulates blood pressure by suppressing WNK1-SPAK/OSR1 signaling in the kidney. Nature Communications, 3, 1285 (2012). 11. Lin, F. R., Huang, S. Y., Hung, K. H., Su, S. T., Chung, C. H., Matsuzawa, A., Hsiao, M., Ichijo, H., Lin, K. I. ASK1 promotes apoptosis of normal and malignant plasma cells. Blood, 120, 1039-1047 (2012). 12. Fujisawa, T., Kengo, H., Yamaguchi, N., Kadowaki, H., Tsuburaya, N., Naguro, I., Matsuzawa, A., Takeda, K., Takahashi, Y., Goto, J., Tsuji, S., Nishitoh, H., Ichijo, H. A novel monoclonal antibody reveals a conformational alteration shared by amyotrophic lateral sclerosis-linked SOD1 mutants. Annals of Neurology, 72, 739-749 (2012). 13. *Tseng, P. H., *Matsuzawa, A., Zhang, W., Mino, T., Vignali, D. A., Karin, M. Different modes of ubiquitination of the adaptor TRAF3 selectively activate the expression of type I interferons and proinflammatory cytokines. Nature Immunology, 11, 70-75 (2010). * These authors contributed equally to this work. 14. Guo, X., Harada, C., Namekata, K., Matsuzawa, A., Camps, M., Ji, H., Swinnen, D., Jorand-Lebrun, C., Muzerelle, M., Vitte, P. A., Ruckle, T., Kimura, A., Kohyama, K., Matsumoto, Y., Ichijo, H., Harada, T. Regulation of the severity of neuroinflammation and demyelination by TLR- ASK1-p38 pathway. EMBO Molecular Medicine, 2, 504-515 (2010). 15. Maruyama, T., Kadowaki, H., Okamoto, N., Nagai, A., Naguro, I., Matsuzawa, A., Shibuya, H., Tanaka, K., Murata, S., Takeda, K., Nishitoh, H., Ichijo, H. CHIP-dependent termination of MEKK2 regulates temporal ERK activation required for proper hyperosmotic response. EMBO Journal, 29, 2501-2514 (2010). 16. Nagai, H., Noguchi, T., Homma, K., Katagiri, K., Takeda, K., Matsuzawa, A., Ichijo, H. Ubiquitin-like sequence in ASK1 plays critical roles in the recognition and stabilization by USP9X and oxidative stress-induced cell death. Molecular Cell, 36, 805-818 (2009). 17. Cekic, C., Casella, C. R., Eaves, C. A., Matsuzawa, A., Ichijo, H., Mitchell, T. C. Selective activation of the p38 MAPK pathway by synthetic monophosphoryl lipid A. J. Biol. Chem., 284, 31982-31991 (2009). 18. Iriyama, T., Takeda, K., Nakamura, H., Morimoto, Y., Kuroiwa, T., Mizukami, J., Umeda, T., Noguchi, T., Naguro, I., Nishitoh, H., Saegusa, K., Tobiume, K., Homma, T., Shimada, Y., Tsuda, H., Aiko, S., Imoto, I., Inazawa, J., Chida, K., Kamei, Y., Kozuma, S., Taketani, Y., Matsuzawa, A., Ichijo, H. ASK1 and ASK2 differentially regulate the counteracting roles of apoptosis and inflammation in tumorigenesis. EMBO Journal, 28, 843-853 (2009). 19. *Matsuzawa, A., *Tseng, P. H., Vallabhapurapu, S., Luo, J. L., Zhang, W., Wang, H., Vignali, D. A., Gallagher, E., Karin, M. Essential cytoplasmic translocation of a cytokine receptor-assembled signaling complex. Science, 321, 663-668 (2008). Research Article. * These authors contributed equally to this work. 20. *Vallabhapurapu, S., *Matsuzawa, A., Zhang, W., Tseng, P. H., Keats, J. J., Wang, H., Vignali, D. A., Bergsagel, P. L., Karin, M. Nonredundant and complementary functions of TRAF2 and TRAF3 in a ubiquitination cascade that activates NIK-dependent alternative NF-kB signaling. Nature Immunology, 9, 1364-1370 (2008). * These authors contributed equally to this work. 21. Wang, H., Matsuzawa, A., Brown, S. A., Zhou, J., Guy, C. S., Tseng, P. H., Forbes, K., Nicholson, T. P., Sheppard, P. W., Hacker, H., Karin, M., Vignali, D. A. Analysis of nondegradative protein ubiquitylation with a monoclonal antibody specific for lysine-63-linked polyubiquitin. Proc. Natl. Acad. Sci. U. S. A., 105, 20197-20202 (2008). 22. Sakurai, T., He, G., Matsuzawa, A., Yu, G. Y., Maeda, S., Hardiman, G., Karin, M. Hepatocyte necrosis induced by oxidative stress and IL-1b release mediate carcinogen-induced compensatory proliferation and liver tumorigenesis. Cancer Cell, 14, 156-165 (2008). 23. Nishitoh, H., Kadowaki, H., Nagai, A., Maruyama, T., Yokota, T., Fukutomi, H., Noguchi, T., Matsuzawa, A., Takeda, K., Ichijo, H. ALS-linked mutant SOD1 induces ER stress- and ASK1-dependent motor neuron death by targeting Derlin-1. Genes & Development, 22, 1451-1464 (2008). 24. Noguchi, T., Ishii, K., Fukutomi, H., Naguro, I., Matsuzawa, A., Takeda, K., Ichijo H. Requirement of reactive oxygen species- dependent activation of ASK1-p38 MAPK pathway for extracellular ATP-induced apoptosis in macrophage. J. Biol. Chem., 283, 7657-7665 (2008). 25. Fujino, G., Noguchi, T., Matsuzawa, A., Yamauchi, S., Saitoh, M., Takeda, K., Ichijo, H. Thioredoxin and TRAF family proteins regulate reactive oxygen species-dependent activation of ASK1 through reciprocal modulation of the N-terminal homophilic interaction of ASK1. Mol. Cell. Biol., 27, 8152-8163 (2007). 26. Osaka, N., Takahashi, T., Murakami, S., Matsuzawa, A., Noguchi, T., Fujiwara, T., Aburatani, H., Moriyama, K., Takeda, K., Ichijo, H. ASK1-dependent recruitment and activation of macrophages induce hair growth in skin wounds. J. Cell Biol., 176, 903-909 (2007). 27. Takeda, K., Shimozono, R., Noguchi, T., Umeda, T., Morimoto, Y., Naguro, I., Tobiume, K., Saitoh, M., Matsuzawa, A., Ichijo, H. Apoptosis signal-regulating kinase (ASK) 2 functions as a mitogen- activated protein kinase kinase kinase in a heteromeric complex with ASK1. J. Biol. Chem., 282, 7522-7531 (2007). 28. *Gallagher, E., *Enzler, T., *Matsuzawa, A., Anzelon- Mills, A., Otero, D., Holzer, R., Janssen, E., Gao, M., Karin, M. Kinase MEKK1 is required for CD40-dependent activation of the kinases Jnk and p38, germinal center formation, B cell proliferation and antibody production. Nature Immunology, 8, 57-63 (2007). * These authors contributed equally to this work. 29. Chiang, E., Dang, O., Anderson, K., Matsuzawa, A., Ichijo, H., David, M. Apoptosis-regulating signal kinase 1 is required for reactive oxygen species-mediated activation of IFN regulatory factor 3 by lipopolysaccharide. J. Immunol., 176, 5720-5724 (2006). 30. Harada, C., Nakamura, K., Namekata, K., Okumura, A., Mitamura, Y., Iizuka, Y., Kashiwagi, K., Yoshida, K., Ohno, S., Matsuzawa, A., Tanaka, K., Ichijo, H., Harada, T. Role of apoptosis signal- regulating kinase 1 in stress-induced neural cell apoptosis in vivo. Am. J. Pathol., 168, 261-269 (2006). 31. *Matsuzawa, A., *Saegusa, K., Noguchi, T., Sadamitsu, C., Nishitoh, H., Nagai, S., Koyasu, S., Matsumoto, K., Takeda, K., Ichijo, H. ROS-deepndent activation of TRAF6-ASK1-p38 pathway is selectively required for TLR4-mediated innate immunity. Nature Immunology, 6, 587-592 (2005). 　 * These authors contributed equally to this work. 32. Noguchi, T., Takeda, K., Matsuzawa, A., Saegusa, K., Nakano, H., Gohda, J., Inoue, J.I., Ichijo, H. Recruitment of TRAF family proteins to the ASK1 signalosome is essential for oxidative stress-induced cell death. J. Biol. Chem., 280, 37033-37040 (2005). 33. Izumi, Y., Kim-Mitsuyama, S., Yoshiyama, M., Omura, T., Shiota, M., Matsuzawa, A., Yukimura, T., Murohara, T., Takeya, M., Ichijo, H., Yoshikawa, J., Iwao, H. Important Role of Apoptosis Signal- Regulating Kinase 1 in Ischemia-induced Angiogenesis. Arterioscler. Thromb. Vasc. Biol., 25, 1877-1883 (2005). 34. Kadowaki, H., Nishitoh, H., Urano, F., Sadamitsu, C., Matsuzawa, A., Takeda, K., Masutani, H., Yodoi, J., Urano, Y., Nagano, T., Ichijo, H. Amyloid b induces neuronal cell death through ROS-mediated ASK1 activation. Cell Death Differ., 12, 19-24 (2005). 35. Takeda, K., Matsuzawa, A., Nishitoh, H., Tobiume, K., Kishida, S., Ninomiya-Tsuji, J., Matsumoto, K., Ichijo H. Involvement of ASK1 in Ca2+-induced p38 MAP kinase activation. EMBO Reports, 5, 161-166 (2004). 36. Yamaguchi, O., Watanabe, T., Nishida, K., Kashiwase, K., Higuchi, Y., Takeda, T., Hikoso, S., Hirotani, S., Asahi, M., Taniike, M., Nakai, A., Tsujimoto, I., Matsumura, Y., Miyazaki, J., Chien, K.R., Matsuzawa, A., Sadamitsu, C., Ichijo, H., Baccarini, M., Hori, M., Otsu, K. Cardiac-specific disruption of the c-raf-1 gene induces cardiac dysfunction and apoptosis. J. Clin. Invest., 114, 937-943 (2004). 37. Izumiya, Y., Kim, S., Izumi, Y., Yoshida, K., Yoshiyama, M., Matsuzawa, A., Ichijo, H., Iwao, H. Apoptosis signal- regulating kinase 1 plays a pivotal role in angiotensin II-induced cardiac hypertrophy and remodeling Circ. Res., 93, 874-83 (2003). 38. Izumi, Y., Kim, S., Yoshiyama, M., Izumiya, Y., Yoshida, K., Matsuzawa, A., Koyama, H., Nishizawa, Y., Ichijo, H., Yoshikawa, J., Iwao, H. Activation of apoptosis signal-regulating kinase 1 in injured artery and its critical role in neointimal hyperplasia. Circulation, 108, 2812-2818 (2003). 39. Hara, K., Honma, T., Matsuzawa, A., Matsuzawa, A., Uchida, M., Koizumi, T., Akahane, S., Kojima, M. Characteristics of the hemostatic action of KFA-1411, an inhibitor of coagulation factor Xa (FXa), in humans and various animals. J. Toxicol. Sci., 28, 25-34 (2003). 40. Jibiki, I., Hashimoto, S., Maruoka, S., Gon, Y., Matsuzawa, A., Nishitoh, H., Ichijo, H., Horie, T. Apoptosis signal-regulating kinase 1-mediated signaling pathway regulates nitric oxide-induced activator protein-1 activation in human bronchial epithelial cells. Am. J. Respir. Cri. Care. Med., 167, 856-861 (2002). 41. Matsuura, H., Nishitoh, H., Takeda, K., Matsuzawa, A., Amagasa, T., Ito, M., Yoshioka, K. Ichijo, H. Phosphorylation-dependent scaffolding role of JSAP1/JIP3 in the ASK1-JNK signaling pathway: A new mode of regulation of the MAP kinase cascade. J. Biol. Chem., 277, 40703-40709 (2002). 42. Nishitoh, H., Matsuzawa, A., Tobiume, K., Saegusa, K., Takeda, K., Inoue, K., Hori, S., Ishikawa, K., Mizusawa, H., Kakizuka, A. Ichijo, H. ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeats. Genes & Development, 16, 1345-1355 (2002). 43. *Tobiume, K., *Matsuzawa, A., Takahashi, T., Nishitoh, H., Morita, K., Takeda, K., Minowa, O., Miyazono, K., Noda, T., Ichijo, H. ASK1 is required for sustained activations of JNK/p38 MAP kinases and apoptosis. EMBO Reports, 2, 222-228 (2001). 　 * These authors contributed equally to this work. 44. Hatai, T., Matsuzawa, A., Inoshita, S., Mochida, Y., Kuroda, T., Sakamaki, K., Kuida, K., Yonehara, S., Ichijo, H., Takeda, K. Execution of apoptosis signal-regulating kinase 1 (ASK1)-induced apoptosis by the mitochondria-dependent caspase activation. J. Biol. Chem., 275, 26576-26581 (2000). 45. Matsuzawa, A., Hattori, K., Aoki, J., Arai, H., Inoue K. Protection against oxidative stress-induced cell death by intracellular platelet-activating factor-acetylhydrolase II. J. Biol. Chem., 272, 32315-32320 (1997). 46. Hattori, K., Adachi, H., Matsuzawa, A., Yamamoto, K., Tsujimoto, M., Aoki, J., Hattori, M., Arai, H., Inoue, K. cDNA cloning and expression of intracellular platelet-activating factor (PAF) acetylhydrolase II. Its homology with plasma PAF acetylhydrolase. J. Biol. Chem., 271, 33032-33038 (1996). 47. Matsuzawa, A., Murakami, M., Atsumi, G., Imai, K., Prados, P., Inoue, K., Kudo, I. Release of secretory phospholipase A2 from rat neuronal cells and its possible function in the regulation of catecholamine secretion. Biochem. J., 318, 701-709 (1996). 48. Kudo, I., Matsuzawa, A., Imai, K., Murakami, M., Inoue, K. Function of type II phospholipase A2 in dopamine secretion by rat neuronal PC12 cells. J. Lipid Mediat. Cell Signal., 14, 25-31 (1996). 49. Murakami, M., Kudo, I., Umeda, M., Matsuzawa, A., Takeda, M., Komada, M., Fujimori. Y., Takahashi, K., Inoue, K. Detection of three distinct phospholipases A2 in cultured mast cells. J. Biochem., 111, 175-181 (1992). Page Top

□□　Review article　□□ NEW!! 1. Matsuzawa, A. Thioredoxin and redox signaling: Roles of the thioredoxin system in control of cell fate. Arch. Biochem. Biophys., 617, 101-105 (2017). 2. Hirata, Y., Takahashi, M., Morishita, T., Noguchi, T., Matsuzawa, A.. Post-Translational Modifications of the TAK1-TAB Complex. Int. J. Mol. Sci.,18, E205 (2017). 3. Soga, M., Matsuzawa, A., Ichijo, H. Oxidative stress- induced diseases via the ASK1 signaling pathway. Int. J. Cell Biol., 2012, 439587 (2012). 4 Takeda, K., Naguro, I., Nishitoh, H., Matsuzawa, A., Ichijo, H. Apoptosis signaling kinases: from stress response to health outcomes. Antioxid. Redox Signal., 15, 719-761 (2011). 5. Runchel, C., Matsuzawa, A., Ichijo, H. Mitogen-activated protein kinases in Mammalian oxidative stress responses. Antioxid. Redox Signal., 15, 205-218 (2011). 6. Katagiri, K., Matsuzawa, A., Ichijo, H. Regulation of apoptosis signal-regulating kinase 1 in redox signaling. Methods Enzymol., 474C, 277-288 (2010). 7. Matsuzawa, A., Takeda, K., Ichijo, H. “ASK1” (doi:10.1038/mp.a002816.01). UCSD-Nature Signaling Gateway, Nature Publishing Group, (2010). 8. Matsuzawa, A., Ichijo, H. Redox control of cell fate by MAP kinase: physiological roles of ASK1-MAP kinase pathway in stress signaling. Biochim. Biophys. Acta., 1780, 1325-1336 (2008). 9. Hayakawa, T., Matsuzawa, A., Noguchi, T., Takeda, K., Ichijo, H. The ASK1-MAP kinase pathways in immune and stress responses. Microbes Infect., 8, 1098-1107 (2006). 10. Matsuzawa, A., Ichijo, H. Stress-responsive protein kinases in redox-regulated apoptosis signaling. Antioxid. Redox Signal., 7, 472-481 (2005). 11 Matsukawa, J., Matsuzawa, A., Takeda, K., Ichijo, H. The ASK1-MAP kinase cascades in mammalian stress response. J. Biochem., 136, 261-265 (2004). 12. Takeda, K., Matsuzawa, A., Nishitoh, H., Ichijo, H. Roles of MAPKKK ASK1 in stress-induced cell death. Cell Struct. Funct., 28, 23-29 (2003). 13. Matsuzawa, A., Nishitoh, H., Tobiume, K., Takeda, K. Ichijo, H. Physiological roles of ASK1-mediated signal transduction in oxidative stress- and endoplasmic reticulum stress-induced apoptosis: advanced findings from ASK1 knockout mice. Antioxid. Redox Signal., 4, 415-425 (2002). 14 Matsuzawa, A., Ichijo, H. Molecular mechanisms of the decision between life and death: regulation of apoptosis by apoptosis signal-regulating kinase 1. J. Biochem., 130, 1-8 (2001). Page Top

□□　Book　□□ 1. Matsuzawa, A., Nishitoh, H., Takeda, K., Ichijo, H. “MAP Kinases in Redox Signaling” in “Signal Transduction by Reactive Oxygen and Nitrogen Species: Pathways and Chemical Principles” ed. by Forman, H.J., Fukuto, J., Torres, M., Kluwer Academic, 223-236 (2003). Page Top

□□　Japanese Review　□□ 1. 松沢厚：レドックス応答キナー・[ASK1による細胞機能の制御， 別冊・医学のあゆみ「レドックスUPDATE−ストレス制御の臨床医学・健康 科学」， 医歯薬出版，75-79，2015. 2. 松沢厚，岡田匡央：リソソーム破裂によるインフラマソームの活性化， 細胞工学， 秀潤社，34(6), 562-566，2015. 3. 松沢厚：多様なユビキチン化酵素群によるリン酸化シグナルの制御機構， 生化学，日本生化学会，87(1), 116-121，2015. 4. 松沢厚，一條秀憲：シグナル伝達系，新臨床腫瘍学〜がん 薬物療法専門医のために〜 (改訂第3版)，日本臨床腫瘍学会 編，南江堂， 14-21，2012． 5. 松沢厚，一條秀憲：ストレス応答キナーゼシグナルの破綻と疾患 ，細胞工学，秀潤社，31(2)，138-143，2012. 6. 松沢厚，一條秀憲：ストレス応答キナーゼシグナルによる細胞死 のバランス制御，実験医学 増刊「細胞死研究 総集編」, 実験医学 ，羊土社，28(7)，1003-1010，2010. 7. 松沢厚，一條秀憲：シグナル伝達系，新臨床腫瘍学〜がん 薬物療法専門医のために〜 (改訂第2版)，日本臨床腫瘍学会 編，南江堂， 16-24，2009． 8. 松沢厚：ユビキチン化によるリン酸化シグナルの新たな時空間的活性制御　-MAPキナーゼシグナル複合体の受容体から細胞質移行によ・EE驫・ｫ化-， 生化学，日本生化学会，81(9), 801-806，2009. 9. 松沢厚，Michael Karin：キナーゼ複合体の受容体から細胞質移 行による時空間的活性制御，実験医学, 羊土社，26(19)，3066-3069 ，2008. 10. 松沢厚，一條秀憲：ストレス応答キナーゼASK1による新たな自然 免疫シグナルの制御機構 -活性酸素を介したASK1-p38経路のTLR4下流特異的活性化-, エンドトキシン研究9 自然免疫の最前線，日本エ・塔hトキシン研究 会 編，医学図書出版，9-17，2006. 11. 名黒功，松沢厚，藤野悟央，一條秀憲：ASK1シグナリングの Redoxによる制御と自然免疫応答への関与，Annual Review免疫2007 ，奥村康・平野俊夫・佐藤昇志編，・・O医学社，73-84，2006． 12. 松沢厚，一條秀憲：ストレス応答キナーゼASK1による自然免疫シ グナルの制御機構-活性酸素を介したTRAF6-ASK1-p38経路のTLR4下流特異的活性化? ，臨床免疫, 科学評論社，45(1)，79-84，2006． 13. 松沢厚，三枝かおる，一條秀憲：ストレス応答キナーゼASK1に よる新たな自然免疫シグナル制御機構の発見：活性酸素が自然免疫応答に果たす役 割，細胞工学，秀潤社，24(7)，706-707，2005. 14. 三輪崇志，松沢厚，一條秀憲：アポトーシス，酸化スト レスナビゲーター，倉林正彦監修，山岸昌一編，メディカルビュー社， 112-113，2005． 15. 松沢厚，三枝かおる，一條秀憲：ストレス応答キナーゼASK1に よる自然免疫シグナルの制御機構，Annual Review 免疫 2005，奥村 康・平野俊夫・佐・｡昇志編，中外医学社，70-80，2004． 16. 松沢厚，一條秀憲： MAPKによるアポトーシスシグナルの制御機・\-ストレス誘導性アポトーシスにおけるASK1の生理的役割-，臨床免疫 特 別増刊号「アポトーシスのすべて」，臨床免疫，科学評論社，38(20)，79 -90，2002． 17. 松沢厚，一條秀憲：(特集)アポトーシス-分子メカニズムとその 破綻が引き起こす疾患-，ストレス応答キナーゼによるアポトーシスシグナルの制御 と疾患-ASK1依存性・Aポトーシスシグナルと疾患との関連-，Molecular Medicine，中山書店，39(6)， 660-670，2002． 18. 松沢厚，森田圭一，一條秀憲：ASK1によるストレス誘導性アポ トーシスと疾患 ASK1ノックアウトマウスの解析から，「酸化ストレス　フリーラジカル医学生物学の最前線」，医歯薬出版，76-81，2001． 19. 松沢厚，一條秀憲：神経細胞におけるアポトーシス制御因子とその制御機構，生体の科学，医学書院，51(4)，266-272，2000．

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